Olaf van Tellingen Selected Research

7-hydroxymethotrexate

8/2011	Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate.
8/2004	Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions.

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Olaf van Tellingen Research Topics

Disease

48	Neoplasms (Cancer) 01/2022 - 08/2004
29	Breast Neoplasms (Breast Cancer) 01/2020 - 04/2002
14	Glioma (Gliomas) 01/2020 - 04/2005
13	Glioblastoma (Glioblastoma Multiforme) 11/2018 - 04/2005
10	Brain Neoplasms (Brain Tumor) 01/2021 - 07/2003
3	Diffuse Intrinsic Pontine Glioma 01/2020 - 01/2018
1	Melanoma (Melanoma, Malignant) 01/2022
1	Prostatic Neoplasms (Prostate Cancer) 10/2021
1	Rhabdoid Tumor (Rhabdoid Tumors) 11/2020
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2020
1	Infertility (Sterility) 01/2020
1	Cardiotoxicity 01/2020
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020
1	Poisoning 01/2020
1	Neoplasm Metastasis (Metastasis) 10/2019
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2019
1	Carcinogenesis 07/2018
1	Chromosomal Instability (Chromosome Stability) 01/2018
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 06/2017

Drug/Important Bio-Agent (IBA)

25	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2002
20	Pharmaceutical PreparationsIBA 01/2021 - 08/2004
18	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2020 - 03/2003
7	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2021 - 09/2005
6	Adenosine Triphosphate (ATP)IBA 01/2020 - 07/2007
5	ElacridarIBA 01/2018 - 07/2003
5	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2014 - 07/2007
4	dipinacoline glutamateIBA 01/2020 - 10/2015
4	AnthracyclinesIBA 01/2020 - 01/2013
4	Temozolomide (Temodar)FDA LinkGeneric 11/2018 - 05/2014
3	Docetaxel (Taxotere)FDA Link 01/2021 - 07/2007
3	Phosphotransferases (Kinase)IBA 01/2021 - 01/2018
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2020 - 01/2018
3	Etoposide (VP 16)FDA LinkGeneric 01/2020 - 03/2003
3	Histones (Histone)IBA 01/2020 - 01/2013
3	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 01/2012
3	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2018 - 08/2008
3	ATP-Binding Cassette Sub-Family B Member 4IBA 10/2013 - 12/2007
3	Topotecan (Hycamtin)FDA LinkGeneric 01/2012 - 11/2007
3	Methotrexate (Mexate)FDA LinkGeneric 08/2011 - 08/2004
2	Biological ProductsIBA 10/2021 - 10/2017
2	ChromatinIBA 01/2020 - 01/2013
2	PoisonsIBA 01/2020 - 02/2010
2	Glutamine (L-Glutamine)FDA Link 10/2019 - 02/2016
2	Cisplatin (Platino)FDA LinkGeneric 01/2019 - 07/2007
2	GSK-2816126IBA 01/2019 - 10/2015
2	RNA (Ribonucleic Acid)IBA 01/2019 - 01/2018
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 11/2018 - 05/2014
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 11/2018 - 02/2010
2	Taxoids (Taxanes)IBA 01/2018 - 09/2005
2	dactolisibIBA 03/2017 - 07/2012
2	Cyclin-Dependent Kinase Inhibitor p16IBA 05/2014 - 07/2010
2	LuciferasesIBA 01/2014 - 07/2007
2	ST 1481 (Gimatecan)IBA 04/2013 - 12/2007
2	Multidrug Resistance-Associated ProteinsIBA 04/2013 - 08/2011
2	Irinotecan (Camptosar)FDA LinkGeneric 04/2013 - 01/2012
2	tryptoquivalineIBA 01/2013 - 04/2002
2	Topoisomerase I InhibitorsIBA 01/2012 - 02/2010
2	7-hydroxymethotrexateIBA 08/2011 - 08/2004
2	Imatinib Mesylate (Gleevec)FDA Link 02/2009 - 04/2005
2	TrabectedinIBA 01/2009 - 02/2007
2	Tyrosine Kinase InhibitorsIBA 08/2008 - 04/2005
1	Heparitin Sulfate (Heparan Sulfate)IBA 01/2022
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2022
1	Testosterone (Sustanon)FDA Link 10/2021
1	Biomarkers (Surrogate Marker)IBA 10/2021
1	enzalutamideIBA 10/2021
1	TropomyosinIBA 01/2021
1	selitrectinibIBA 01/2021
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2021
1	AclarubicinIBA 01/2020
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2020
1	trioctyl phosphine oxide (TOPO)IBA 01/2020
1	Type II DNA Topoisomerases (Topoisomerase II)IBA 01/2020
1	Asparaginase (Elspar)FDA Link 10/2019
1	Amino Acid Transport System X-AG (Glutamate Transporter)IBA 10/2019
1	Glutamic Acid (Glutamate)FDA Link 10/2019
1	AsparagineIBA 10/2019
1	Aspartic Acid (Aspartate)FDA Link 10/2019
1	PlatinumIBA 01/2019
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2019
1	1- (6- (3,5- dichloro- 4- hydroxyphenyl)- 4- ((4- ((dimethylamino)methyl)cyclohexyl)amino)- 1,5- naphthyridin- 3- yl)ethanoneIBA 11/2018
1	Antineoplastic Agents (Antineoplastics)IBA 11/2018
1	AZD2461IBA 11/2018
1	NVP-BKM120IBA 07/2018
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 07/2018
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2018
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2018
1	Chemokine ReceptorsIBA 01/2018
1	Carrier Proteins (Binding Protein)IBA 01/2018
1	mirdametinibIBA 01/2018
1	LigandsIBA 01/2018
1	Casein Kinase II (Casein Kinase 2)IBA 01/2018
1	MitogensIBA 01/2018
1	Alkylating AgentsIBA 01/2018
1	Eph Family Receptors (Eph Receptors)IBA 01/2018
1	Serotonin (5 Hydroxytryptamine)IBA 06/2017

Therapy/Procedure

20	Therapeutics 01/2022 - 07/2007
9	Drug Therapy (Chemotherapy) 01/2019 - 04/2002
1	Castration 10/2021
1	Radiotherapy 10/2017